Paediatrics
Paediatrics

The immune landscape of pediatric (extra)cranial solid tumors: A systematic review and integration of immunohistochemistry and single-cell RNA sequencing data

Eur J Cancer. 2025 Aug 12;228:115708. doi: 10.1016/j.ejca.2025.115708. Online ahead of print. ABSTRACT BACKGROUND: Immunotherapies achieved remarkable success in adult cancers, yet their efficacy in …

Increased Body Mass Index and Ventricular Cardiac Magnetic Resonance Characteristics in Adults With Fontan Circulation

JACC Adv. 2025 Aug 25;4(9):102094. doi: 10.1016/j.jacadv.2025.102094. Online ahead of print. ABSTRACT BACKGROUND: In structurally normal hearts, increased body mass index (BMI) is associated with …

Generation of a human PBMC induced pluripotent stem cell line JXEYi001-A-iPSC from a pediatric patient with ventricular arrhythmias

Stem Cell Res. 2025 Aug 22;88:103815. doi: 10.1016/j.scr.2025.103815. Online ahead of print. ABSTRACT This study established an iPSC line, JXEYi001-A, from a 7-year-old male with …

Effectiveness and safety of perampanel by concomitant antiseizure medications: Insights from the real-world PERMIT Extension study

Epilepsy Behav. 2025 Aug 25;171:110651. doi: 10.1016/j.yebeh.2025.110651. Online ahead of print. ABSTRACT The PERMIT Extension study is the largest pooled analysis of perampanel (PER) clinical …

Home-Based mHealth Platform (Active-Feet) for Children With Idiopathic Toe Walking: Design, Development, and Acceptability Study

JMIR Rehabil Assist Technol. 2025 Aug 26;12:e60867. doi: 10.2196/60867. ABSTRACT BACKGROUND: Physical exercise and stretching programs are the best initial options to treat idiopathic toe …

LEF1 Intragenic Deletion Induces a Dominant-Negative isoform and unveils a Wnt/β3-Catenin Vulnerability in T-ALL

Blood. 2025 Aug 26:blood.2025030161. doi: 10.1182/blood.2025030161. Online ahead of print. ABSTRACT T-cell acute lymphoblastic leukemia (T-ALL) represents a group of aggressive hematological malignancies characterized by …

Genomic heterogeneity and lineage-specific beta-lactamases in recurrent Achromobacter bloodstream infection patients

Emerg Microbes Infect. 2025 Dec;14(1):2547721. doi: 10.1080/22221751.2025.2547721. Epub 2025 Aug 26. ABSTRACT Recurrent Achromobacter infections pose significant clinical challenges due to antimicrobial resistance and within-host …