Paediatrics
Paediatrics

Dynamic assessment of a humanized bone tumour microenvironment reveals insights into osteosarcoma primary tumour remodelling and lung metastases

Sci Rep. 2025 Nov 28. doi: 10.1038/s41598-025-29941-z. Online ahead of print. ABSTRACT Osteosarcoma (OS) is the most common primary bone cancer in children and adolescents, …

Inclusion of JNK-independent drugs within multiagent chemotherapy improves response in relapsed high-risk neuroblastoma

Sci Adv. 2025 Nov 28;11(48):eady5599. doi: 10.1126/sciadv.ady5599. Epub 2025 Nov 28. ABSTRACT The acquisition of a chemoresistant state underlies poor prognosis in many cancers, including …

Maternal allergy and neonatal RSV infection synergize via FcR-mediated allergen uptake to promote the development of asthma in early life

Sci Immunol. 2025 Nov 28;10(113):eadz4626. doi: 10.1126/sciimmunol.adz4626. Epub 2025 Nov 28. ABSTRACT Allergic asthma arises from complex genetic and environmental interactions. Analysis of a population-wide …

Metabolic reprogramming in Fanconi anemia: Evidence of compromised glucose oxidation, enhanced ketogenesis, and metabolic inflexibility

Sci Adv. 2025 Nov 28;11(48):eady6117. doi: 10.1126/sciadv.ady6117. Epub 2025 Nov 28. ABSTRACT Fanconi anemia (FA) is a rare genetic disorder characterized by congenital abnormalities, bone …