Paediatrics
Paediatrics

Impact of Childhood Neighborhood Deprivation on White Matter and Functional Connectivity During Adolescence

J Neuroimaging. 2025 Sep-Oct;35(5):e70087. doi: 10.1111/jon.70087. ABSTRACT BACKGROUND AND PURPOSE: Socioeconomic determinants of health impact childhood development and adult health outcomes. One key aspect is …

Remodeling the sarcoma microenvironment by simultaneous targeting of urokinase-type plasminogen activator receptors and epidermal growth factor receptors to promote antitumor activity

J Pharmacol Exp Ther. 2025 Aug 18;392(9):103674. doi: 10.1016/j.jpet.2025.103674. Online ahead of print. ABSTRACT We evaluated the antitumor effects of remodeling the MC17 mouse sarcoma …

ADSL deficiency is a secondary mitochondrial disease affecting organelle homeostasis and ERK2/AKT signaling in a linear genotype-phenotype relation

Cell Rep. 2025 Sep 5;44(9):116230. doi: 10.1016/j.celrep.2025.116230. Online ahead of print. ABSTRACT Adenylosuccinate lyase deficiency (ADSLd) is a rare autosomal recessive purine metabolism disorder with …