Paediatrics
Paediatrics

NUDT21 Drives T-Cell Acute Lymphoblastic Leukemia Through Dual Regulation of Alternative Polyadenylation and Transcriptional Activation

Adv Sci (Weinh). 2026 Apr 2:e20693. doi: 10.1002/advs.202520693. Online ahead of print. ABSTRACT T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy with limited …

Tirzepatide and metformin effects on hunger and BMI in an adolescent with hyperphagia and severe obesity due to MC4R Deficiency: a case report

Obes Facts. 2026 Apr 2:1-13. doi: 10.1159/000551729. Online ahead of print. ABSTRACT INTRODUCTION: Tirzepatide, a dual GLP-1/GIP receptor agonist, is recently approved for the treatment …

Physics-informed graph neural networks for robust cross-patient epileptic seizure prediction via chimera state detection

PLoS One. 2026 Apr 2;21(4):e0345470. doi: 10.1371/journal.pone.0345470. eCollection 2026. ABSTRACT BACKGROUND: Epilepsy affects approximately 50 million individuals worldwide, with 30% experiencing drug-resistant seizures despite optimal …

Analysis of the Impact of Preterm Premature Rupture of Membranes (PPROM) on Maternal and Infant Outcomes and Countermeasures

Int J Womens Health. 2026 Jan 15;18:534571. doi: 10.2147/IJWH.S534571. eCollection 2026. ABSTRACT OBJECTIVE: This study aimed to analyze the risk factors for Preterm Premature Rupture …