Paediatrics
Paediatrics

Pathogenesis of Noonan syndrome is modulated by NOC2L, a novel interactor of LZTR1 leading to impaired p53 signalling

J Clin Endocrinol Metab. 2025 Nov 1:dgaf602. doi: 10.1210/clinem/dgaf602. Online ahead of print. ABSTRACT INTRODUCTION: Monoallelic dominant-negative LZTR1 gene variants have been implicated as a …

Pediatric Pancreatoblastoma with an NRAS Mutation: Expanding the Spectrum of Genetic Alterations in Pancreatoblastoma

Pediatr Dev Pathol. 2025 Nov 1:10935266251389480. doi: 10.1177/10935266251389480. Online ahead of print. ABSTRACT Pancreatoblastoma is a rare malignancy that primarily affects children and involves abnormalities …

Storage protein allergen sensitization patterns in children: Insights from multiplex microarray profiling and hierarchical clustering

Pediatr Allergy Immunol. 2025 Nov;36(11):e70233. doi: 10.1111/pai.70233. ABSTRACT BACKGROUND: Storage proteins (SPs), including 2S albumins, vicilins, and legumins, are key allergenic molecules (AMs) of peanuts, …

Preparation of a cardiopulmonary bypass priming solution for infants and neonates – effect of pre-bypass ultrafiltration on heparinization

Perfusion. 2025 Nov 1:2676591251394850. doi: 10.1177/02676591251394850. Online ahead of print. ABSTRACT IntroductionHeparin is usually added to infant cardiopulmonary bypass circuit primes. Ultrafiltration is often used …