Paediatrics
Paediatrics

Targeted-Agent Continual Reassessment Method: A Novel Bayesian Enrichment Design for Phase I Trials of Molecularly Targeted Therapies

JCO Precis Oncol. 2024 Dec;8:e2400360. doi: 10.1200/PO.24.00360. Epub 2024 Dec 23. ABSTRACT PURPOSE: Novel therapies targeting specific genomic alterations are a promising treatment approach for …

Long-Term Clinical and Biological Prognostic Factors of Anti-NMDA Receptor Encephalitis in Children

Neurol Neuroimmunol Neuroinflamm. 2025 Mar;12(2):e200346. doi: 10.1212/NXI.0000000000200346. Epub 2024 Dec 23. ABSTRACT BACKGROUND AND OBJECTIVES: Anti-NMDAR encephalitis (NMDARE) is a severe neurologic condition, and recently, …

Genome-wide CRISPR screen identifies AraC-Dauno-Eto (ADE) response modulators that predicts outcome in pediatric AML

Blood Adv. 2024 Dec 23:bloodadvances.2024014157. doi: 10.1182/bloodadvances.2024014157. Online ahead of print. ABSTRACT Cytarabine, daunorubicin, and etoposide (ADE) have been the standard backbone of induction chemotherapy …

Distinguishing Transient From Persistent Brain Structural Changes in Pediatric Patients With Acute Disseminated Encephalomyelitis

Neurol Neuroimmunol Neuroinflamm. 2025 Jan;12(1):e200337. doi: 10.1212/NXI.0000000000200337. Epub 2024 Dec 23. ABSTRACT BACKGROUND AND OBJECTIVES: Pediatric patients with acute disseminated encephalomyelitis (ADEM) are at risk …