Synthetic lethality of EZH2 and DNMT Inhibition suppresses neuroblastoma proliferation via MYCN destabilization
BMC Cancer. 2025 Nov 12;25(1):1759. doi: 10.1186/s12885-025-14882-7. NO ABSTRACT PMID:41225513 | DOI:10.1186/s12885-025-14882-7
Paediatrics
Systematic review of indirect costs to families of children with developmental epileptic encephalopathies
Orphanet J Rare Dis. 2025 Nov 12;20(1):579. doi: 10.1186/s13023-025-04081-9. NO ABSTRACT PMID:41225515 | DOI:10.1186/s13023-025-04081-9
Heart rate variability (HRV) in juvenile fibromyalgia: a preliminary study
Pediatr Rheumatol Online J. 2025 Nov 12;23(1):114. doi: 10.1186/s12969-025-01163-7. ABSTRACT BACKGROUND: Juvenile fibromyalgia (JFM) is a chronic pain condition affecting children and adolescents, often accompanied …
Association between MRI-derived early second trimester placental physiology and birth weight percentiles in pregnancies without ischemic placenta disease (IPD)
Placenta. 2025 Nov 6;172:120-130. doi: 10.1016/j.placenta.2025.11.003. Online ahead of print. ABSTRACT INTRODUCTION: This study investigated whether placental structure and function, measured using multiparametric MRI (mpMRI) …
A data-driven modeling approach to prediction of persistent foot drop after gastroc-soleus lengthening surgery in children with cerebral palsy
Gait Posture. 2025 Oct 14;124:110010. doi: 10.1016/j.gaitpost.2025.110010. Online ahead of print. ABSTRACT BACKGROUND: Gastrocsoleus lengthening (GSL) is an established surgical intervention for equinus deformity in …
Primary caregivers’ perceptions of challenges in dental and orthodontic care for children with Down syndrome
Int Dent J. 2025 Nov 11;76(1):104016. doi: 10.1016/j.identj.2025.104016. Online ahead of print. ABSTRACT INTRODUCTION AND AIMS: Children with Down syndrome (DS) face increased oral health …
Myosin Inhibitors for the Treatment of Obstructive Hypertrophic Cardiomyopathy: A Canadian Perspective on a First-in-Class Therapy
Can J Physiol Pharmacol. 2025 Nov 12. doi: 10.1139/cjpp-2025-0124. Online ahead of print. ABSTRACT Hypertrophic cardiomyopathy (HCM) is a relatively common heritable cardiac condition (~1 …
Investigating the combined effects of jadomycin B and celecoxib against triple-negative breast cancer using zebrafish larval xenografts
Can J Physiol Pharmacol. 2025 Nov 12. doi: 10.1139/cjpp-2025-0117. Online ahead of print. ABSTRACT Breast cancer affects 1 in 8 Canadian women over their lifetime. …
Impact of Pulmonary Tumor Burden in Favorable Histology Wilms Tumor Outcomes: A Report From the Children’s Oncology Group Study AREN0533
J Clin Oncol. 2025 Nov 12:JCO2500532. doi: 10.1200/JCO-25-00532. Online ahead of print. ABSTRACT PURPOSE: Children with favorable histology Wilms tumor (FHWT) with pulmonary metastases have …
Sex-Specific Effects of Abdominal Aortic Constriction on Renal Cytochrome P450 Enzymes and Arachidonic Acid Metabolites in Male and Female Rats
Can J Physiol Pharmacol. 2025 Nov 12. doi: 10.1139/cjpp-2025-0157. Online ahead of print. ABSTRACT We previously showed that male rats develop more severe cardiac hypertrophy …