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Paediatrics

Emergency Surgical Management of Chemotherapy-Induced Tumor Rupture in a Patient with MYCN-Amplified Neuroblastoma: A Case Report

Surg Case Rep. 2025;11(1):25-0473. doi: 10.70352/scrj.cr.25-0473. Epub 2025 Nov 8. ABSTRACT INTRODUCTION: Tumor rupture with neuroblastoma is an uncommon but serious complication, particularly in high-risk …

Child And Adolescent Mental Health

Mental disorders in childhood and adolescence: a systematic review and meta-analysis of epidemiological data

BMC Psychiatry. 2025 Nov 13;25(1):1087. doi: 10.1186/s12888-025-07532-6. ABSTRACT BACKGROUND: Mental disorders in children and adolescents are widespread and can have lasting effects on their emotional, …

Child And Adolescent Mental Health

Depressive symptomatology in the first-episode schizophrenia spectrum disorders OPTiMiSE trial: prevalence, correlates, symptom progression and outcomes

Schizophrenia (Heidelb). 2025 Nov 13;11(1):135. doi: 10.1038/s41537-025-00681-3. ABSTRACT Numerous aspects of depressive symptomatology in first-episode schizophrenia spectrum disorders (FES) remain unclear. Based on data from …

Child And Adolescent Mental Health

Efficacy and safety of iclepertin for cognitive impairment associated with schizophrenia (CONNEX programme): results from three phase 3 randomised controlled trials

Lancet Psychiatry. 2025 Dec;12(12):906-920. doi: 10.1016/S2215-0366(25)00296-2. ABSTRACT BACKGROUND: There are no pharmacotherapies available for cognitive impairment associated with schizophrenia (CIAS). The CONNEX programme investigated the …

Child And Adolescent Mental Health

Refugee stigma and its toll on mental health: development and validation of the refugee stigma scale (RSS)

BMJ Glob Health. 2025 Nov 13;10(11):e017276. doi: 10.1136/bmjgh-2024-017276. ABSTRACT BACKGROUND: Unprecedented, forced displacement, especially from conflict and war areas, requires addressing resultant mental health issues. …

Child And Adolescent Mental Health

Metformin for overweight and obese children and adolescents with bipolar spectrum and related mood disorders treated with second-generation antipsychotics: a randomised, pragmatic trial

Lancet Psychiatry. 2025 Dec;12(12):893-905. doi: 10.1016/S2215-0366(25)00273-1. ABSTRACT BACKGROUND: Second-generation antipsychotics are widely used to treat patients with bipolar spectrum disorders and effectively manage mood symptoms …

Child And Adolescent Mental Health

Patterns of co-occurring health risk behaviors and their associations with suicidality among U.S. adolescents: A latent class and decision tree analysis of YRBSS data (2011-2023)

J Affect Disord. 2025 Nov 11:120680. doi: 10.1016/j.jad.2025.120680. Online ahead of print. ABSTRACT BACKGROUND: Suicide rates among U.S. adolescents have risen in parallel with widespread …

Child And Adolescent Mental Health

Prepandemic and Postpandemic: How COVID-19 Pandemic Affected Depression Symptoms in Youth With Epilepsy and Other Neurological Conditions

Pediatr Neurol. 2025 Oct 25;174:135-139. doi: 10.1016/j.pediatrneurol.2025.10.014. Online ahead of print. ABSTRACT BACKGROUND: Children and adolescents with neurological diagnoses are more susceptible to experiencing depressive …