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The Prevention of Developmental Delay and Xylitol (PDDaX) trial: study protocol of a nested cohort follow-up from the PPaX (Prevention of Prematurity and Xylitol) trial examining neurodevelopmental outcomes among offspring at 4-8 years of age in Malawi

Trials. 2025 Nov 14;26(1):506. doi: 10.1186/s13063-025-09204-y. ABSTRACT BACKGROUND: We recently conducted the cluster-randomized, Prevention of Prematurity and Xylitol (PPaX) trial which demonstrated a significant reduction …

Frequency of team simulation and reduction in maternal deaths following Safer Births Bundle of Care implementation-a prospective observational study

Adv Simul (Lond). 2025 Nov 14;10(1):56. doi: 10.1186/s41077-025-00387-7. ABSTRACT BACKGROUND: Safer Births Bundle of Care (SBBC) is a continuous quality improvement (CQI) program, implemented in …

High prevalence and pathogen-specific variations of co-infections in pediatric adenovirus pneumonia: a retrospective epidemiological analysis from Northern China

Ital J Pediatr. 2025 Nov 14;51(1):302. doi: 10.1186/s13052-025-02129-x. ABSTRACT BACKGROUND: To investigate the characteristics of co-infection pathogen profiles in children with adenovirus pneumonia and provide …

Effects of dietary management for medium-chain acyl-CoA dehydrogenase deficiency (MCADD) on eating behaviour in childhood, adolescence and young adulthood

BMC Nutr. 2025 Nov 14;11(1):213. doi: 10.1186/s40795-025-01209-9. ABSTRACT BACKGROUND: Medium-chain acyl-CoA dehydrogenase deficiency (MCADD) is an autosomal recessive disorder of ß-oxidation. A loss of enzyme …

How a major discovery can become a public health failure when used subotptimally: lessons from early nirsevimab implementation

Ital J Pediatr. 2025 Nov 14;51(1):301. doi: 10.1186/s13052-025-02147-9. ABSTRACT BACKGROUND: In this Debate, based on our clinical data from the “pre-nirsevimab” and “first year of …

Automated reporting of primaquine dose efficacy, tolerability and safety for Plasmodium vivax malaria using a systematic review and individual patient data meta-analysis

Malar J. 2025 Nov 14;24(1):400. doi: 10.1186/s12936-025-05642-w. ABSTRACT BACKGROUND: The antirelapse efficacy of primaquine is related to the total dose administered, whereas the risks of …

Exploring barriers and facilitators of preceptorship in undergraduate health professions education: insights from a qualitative needs assessment among preceptors in Eastern Uganda

BMC Med Educ. 2025 Nov 14;25(1):1605. doi: 10.1186/s12909-025-08160-0. ABSTRACT BACKGROUND: Clinical preceptorship plays a critical role in bridging theoretical knowledge and practical skills for health …

Comparative effectiveness of metformin and alogliptin combination therapy versus metformin monotherapy in patients with type 2 diabetes: an emulated target trial

BMC Endocr Disord. 2025 Nov 14;25(1):264. doi: 10.1186/s12902-025-02087-9. ABSTRACT BACKGROUND: As type 2 diabetes mellitus (T2DM) has emerged as a global health challenge, various treatment …

Sleep and Activity Patterns as Transdiagnostic Behavioral Biomarkers in Psychiatry: Longitudinal Observational Study From the DeeP-DD Study

JMIR Form Res. 2025 Nov 14;9:e81107. doi: 10.2196/81107. ABSTRACT BACKGROUND: Despite widespread use of symptom rating scales in psychiatry, these tools are limited by reliance …