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Tanomastat exerts multi-targeted inhibitory effects on viral capsid dissociation and RNA replication in human enteroviruses

EBioMedicine. 2024 Sep 2;107:105277. doi: 10.1016/j.ebiom.2024.105277. Online ahead of print. ABSTRACT BACKGROUND: Global cyclical outbreaks of human enterovirus infections has positioned human enterovirus A71 (EV-A71) …

Concurrent ependymal and ganglionic differentiation in a subset of supratentorial neuroepithelial tumors with EWSR1-PLAGL1 rearrangement

Acta Neuropathol Commun. 2024 Sep 3;12(1):143. doi: 10.1186/s40478-024-01809-9. ABSTRACT Neuroepithelial tumors with fusion of PLAGL1 or amplification of PLAGL1/PLAGL2 have recently been described often with …

RNAseqCovarImpute: a multiple imputation procedure that outperforms complete case and single imputation differential expression analysis

Genome Biol. 2024 Sep 3;25(1):236. doi: 10.1186/s13059-024-03376-7. ABSTRACT Missing covariate data is a common problem that has not been addressed in observational studies of gene …

Increased serum carboxylesterase-1 levels are associated with metabolic dysfunction associated steatotic liver disease and metabolic syndrome in children with obesity

Ital J Pediatr. 2024 Sep 4;50(1):162. doi: 10.1186/s13052-024-01733-7. ABSTRACT BACKGROUND: Carboxylesterase 1(CES1) is expressed mainly in the liver and adipose tissue and is highly hypothesized …