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Pharmacokinetics and Pharmacodynamics of Systemic Corticosteroids in Autoimmune and Inflammatory Diseases: A Review of Current Evidence

Clin Pharmacokinet. 2024 Sep 12. doi: 10.1007/s40262-024-01419-7. Online ahead of print. ABSTRACT BACKGROUND AND OBJECTIVE: Systemic corticosteroids have a long history of use in the …

Performance of patient-collected dried blood spot specimens for HIV-1 viral load testing: evidence from the DO ART Study in South Africa

AIDS. 2024 Sep 12. doi: 10.1097/QAD.0000000000004011. Online ahead of print. ABSTRACT OBJECTIVE: Evaluate the clinical utility of patient-collected dried blood spots (DBS) in measuring HIV-1 …

Physiologically based pharmacokinetic models for systemic disposition of protein therapeutics in rabbits

Front Pharmacol. 2024 Aug 28;15:1427325. doi: 10.3389/fphar.2024.1427325. eCollection 2024. ABSTRACT Physiologically based pharmacokinetic (PBPK) modelling is an important tool to predict drug disposition in the …

Epidemiological trends in respiratory pathogens infections among children post-COVID-19: A cross-sectional study

Heliyon. 2024 Aug 23;10(17):e36809. doi: 10.1016/j.heliyon.2024.e36809. eCollection 2024 Sep 15. ABSTRACT OBJECTIVE: The aim of this study was to investigate the epidemiological trend of respiratory …

Inhibition of cGAS attenuates neonatal hypoxic-ischemic encephalopathy via regulating microglia polarization and pyroptosis

Transl Pediatr. 2024 Aug 31;13(8):1378-1394. doi: 10.21037/tp-24-148. Epub 2024 Aug 28. ABSTRACT BACKGROUND: Neonatal hypoxic-ischemic encephalopathy (HIE) is a condition causing brain injury in newborns …