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Diagnostic efficacy and clinical utility of whole-exome sequencing in Czech pediatric patients with rare and undiagnosed diseases

Sci Rep. 2024 Nov 20;14(1):28780. doi: 10.1038/s41598-024-79872-4. ABSTRACT In the last decade, undiagnosed disease programs have emerged to address the significant number of individuals with …

High detection rate of circulating-tumor DNA from cerebrospinal fluid of children with central nervous system germ cell tumors

Acta Neuropathol Commun. 2024 Nov 20;12(1):178. doi: 10.1186/s40478-024-01886-w. ABSTRACT Central nervous system germ cell tumors (CNS-GCT) are malignant neoplasms that arise predominantly during adolescence and …

Efficacy and tolerability of high-dose cefalexin 45 mg/kg/dose (maximum 1.5 g) three times daily in children with bone and joint infections

J Antimicrob Chemother. 2024 Nov 21:dkae423. doi: 10.1093/jac/dkae423. Online ahead of print. ABSTRACT BACKGROUND: Cefalexin, a first-generation cephalosporin, is commonly used as oral continuation therapy …

Assessing differences among persistent, episodic, and non- high-need high-cost hospitalized children in China after categorization by an unsupervised learning algorithm

Arch Public Health. 2024 Nov 20;82(1):218. doi: 10.1186/s13690-024-01442-x. ABSTRACT BACKGROUND: High-need, high-cost (HNHC) patients are a major focus of international healthcare reform. However, research on …

A randomized clinical trial of intranasal dexmedetomidine versus inhaled nitrous oxide for procedural sedation and analgesia in children

Scand J Trauma Resusc Emerg Med. 2024 Nov 20;32(1):117. doi: 10.1186/s13049-024-01292-0. ABSTRACT BACKGROUND: Procedural sedation and analgesia is an important part of pediatric emergency care, …

Investigation of renal tubular function with newly diagnosed type 1 diabetes mellitus during diabetic ketoacidosis

Diabetol Metab Syndr. 2024 Nov 20;16(1):276. doi: 10.1186/s13098-024-01506-6. ABSTRACT BACKGROUND: Proximal renal tubular dysfunction occurs during diabetic ketoacidosis (DKA) in type 1 diabetes. However, only …