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GNAO1 overexpression promotes neural differentiation of glioma stem-like cells and reduces tumorigenicity through TRIM21/CREB/HES1 axis

Oncogene. 2024 Nov 23. doi: 10.1038/s41388-024-03234-7. Online ahead of print. ABSTRACT Inducing tumor cell differentiation is a promising strategy for treating malignant cancers, including glioma, …

Growing up in a larger body: youth- and parent-reported triggers for illness and barriers to recovery from anorexia nervosa

J Eat Disord. 2024 Nov 23;12(1):192. doi: 10.1186/s40337-024-01156-z. ABSTRACT BACKGROUND: A significant portion of youth with anorexia nervosa (AN) or atypical anorexia nervosa (AAN) have …

Genetic association analysis and frequency of NUDT15*3 with thiopurine-induced myelosuppression in patients with inflammatory bowel disease in a large Dutch cohort

Pharmacogenomics J. 2024 Nov 23;24(6):39. doi: 10.1038/s41397-024-00358-7. ABSTRACT Thiopurine drugs are cornerstone treatment for patients with inflammatory bowel disease (IBD). The most common adverse drug …

The role of interpersonal trust in the associations between parental warmth and depressive symptoms among Chinese adolescents: A mediation analysis

Fam Process. 2024 Nov 23. doi: 10.1111/famp.13084. Online ahead of print. ABSTRACT The rising rates of adolescent depression have become a critical concern, with family …

Technical variability across the 450K, EPICv1, and EPICv2 DNA methylation arrays: lessons learned for clinical and longitudinal studies

Clin Epigenetics. 2024 Nov 22;16(1):166. doi: 10.1186/s13148-024-01761-4. ABSTRACT DNA methylation (DNAm) is the most commonly measured epigenetic mechanism in human populations, with most studies using …

Prefrontal parvalbumin interneurons mediate CRHR1-dependent early-life stress-induced cognitive deficits in adolescent male mice

Mol Psychiatry. 2024 Nov 22. doi: 10.1038/s41380-024-02845-6. Online ahead of print. ABSTRACT Cognitive impairment, a core symptom of psychiatric disorders, is frequently observed in adolescents …

Influence of learning stress on anxiety levels among high school students in China: the chain-mediated role of physical activity and mobile phone addiction

BMJ Open. 2024 Nov 21;14(11):e078488. doi: 10.1136/bmjopen-2023-078488. ABSTRACT OBJECTIVES: The objectives are to explore the relationship between study stress and anxiety in high school students …