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Design, Synthesis and Anti-Inflammatory Evaluation of 3-Substituted 5-Amidobenzoate Derivatives as Novel P2Y14 Receptor Antagonists via Structure-Guided Molecular Hybridization

J Med Chem. 2025 Jan 29. doi: 10.1021/acs.jmedchem.4c01539. Online ahead of print. ABSTRACT The P2Y14R is activated by UDP and UDP glucose and is involved …

Can Surgery Be Proposed to Adolescent Idiopathic Scoliosis Patients With Structural Lumbar Curves Associated With Nonreducible Iliolumbar Angle?

J Pediatr Orthop. 2025 Jan 29. doi: 10.1097/BPO.0000000000002905. Online ahead of print. ABSTRACT BACKGROUND: Lower instrumented vertebra (LIV) selection for adolescent idiopathic scoliosis (AIS) with …

Noncoding variants and sulcal patterns in congenital heart disease: Machine learning to predict functional impact

iScience. 2024 Dec 28;28(2):111707. doi: 10.1016/j.isci.2024.111707. eCollection 2025 Feb 21. ABSTRACT Neurodevelopmental impairments associated with congenital heart disease (CHD) may arise from perturbations in brain …

A randomised controlled implementation trial of the feasibility and effectiveness of school staff delivery of a selective substance use and mental health program during the COVID-19 pandemic

BMC Public Health. 2025 Jan 28;25(1):349. doi: 10.1186/s12889-025-21493-1. ABSTRACT BACKGROUND: Preventure is a selective school-based personality-targeted program that has shown long-term benefits in preventing student …