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Myosin Inhibitors for the Treatment of Obstructive Hypertrophic Cardiomyopathy: A Canadian Perspective on a First-in-Class Therapy

Can J Physiol Pharmacol. 2025 Nov 12. doi: 10.1139/cjpp-2025-0124. Online ahead of print. ABSTRACT Hypertrophic cardiomyopathy (HCM) is a relatively common heritable cardiac condition (~1 …

Investigating the combined effects of jadomycin B and celecoxib against triple-negative breast cancer using zebrafish larval xenografts

Can J Physiol Pharmacol. 2025 Nov 12. doi: 10.1139/cjpp-2025-0117. Online ahead of print. ABSTRACT Breast cancer affects 1 in 8 Canadian women over their lifetime. …

Impact of Pulmonary Tumor Burden in Favorable Histology Wilms Tumor Outcomes: A Report From the Children’s Oncology Group Study AREN0533

J Clin Oncol. 2025 Nov 12:JCO2500532. doi: 10.1200/JCO-25-00532. Online ahead of print. ABSTRACT PURPOSE: Children with favorable histology Wilms tumor (FHWT) with pulmonary metastases have …

Sex-Specific Effects of Abdominal Aortic Constriction on Renal Cytochrome P450 Enzymes and Arachidonic Acid Metabolites in Male and Female Rats

Can J Physiol Pharmacol. 2025 Nov 12. doi: 10.1139/cjpp-2025-0157. Online ahead of print. ABSTRACT We previously showed that male rats develop more severe cardiac hypertrophy …

Rapid qualitative approaches in pandemic research: protocol for an exploratory qualitative multi-method study on mpox in Italy, Nigeria, Thailand and the United Kingdom (VERDIQual)

JMIR Res Protoc. 2025 Nov 12. doi: 10.2196/77321. Online ahead of print. ABSTRACT BACKGROUND: Recent mpox outbreaks have underscored significant gaps in global preparedness for …

A systematic review and meta-analysis of the impact of environmental disadvantage on youth delayed reward discounting

Dev Psychopathol. 2025 Nov 12:1-16. doi: 10.1017/S0954579425100886. Online ahead of print. ABSTRACT Delayed reward discounting (DRD), the tendency to prefer smaller rewards available immediately relative …

Multidimensional Impacts of Elexacaftor/Tezacaftor/Ivacaftor: Comparisons of Physical and Mental Health Providers’ Observations in Cystic Fibrosis in Europe and the United States

Pediatr Pulmonol. 2025 Nov;60(11):e71367. doi: 10.1002/ppul.71367. ABSTRACT BACKGROUND: Elexacaftor/tezacaftor/ivacaftor (ETI) has been associated with improvements in physical health and well-being. However, there are growing concerns …

Resilience in Bipolar Disorder Compared to Clinical and Non-Clinical Populations: A Systematic Review and Meta-Analysis

Acta Psychiatr Scand. 2025 Nov 12. doi: 10.1111/acps.70042. Online ahead of print. ABSTRACT INTRODUCTION: Resilience is present in both clinical and non-clinical populations; yet, there …