JohnJAcademy.com
Blog
Paediatrics

Antisense oligonucleotides targeting valosin-containing protein ameliorate muscle pathology and molecular defects in cell and mouse models of multisystem proteinopathy

Clin Transl Med. 2025 Dec;15(12):e70530. doi: 10.1002/ctm2.70530. ABSTRACT BACKGROUND: Valosin-containing protein (VCP) related disease, also known as multisystem proteinopathy 1 (MSP1), is an autosomal dominant …

Paediatrics

Variation in Hypoglycemia Risk During Real-World Physical Activity in Adults with Type 1 Diabetes: Insights from the Type 1 Diabetes Exercise Initiative

Diabetes Technol Ther. 2025 Dec 3. doi: 10.1177/15209156251400209. Online ahead of print. ABSTRACT Background: Physical activity (PA) poses significant challenges in glucose management for individuals …

Paediatrics

Impact of vaginal estradiol on the genitourinary syndrome of menopause, vaginal microbiome and mucosal immune mediators in women living with HIV

Clin Infect Dis. 2025 Dec 8:ciaf669. doi: 10.1093/cid/ciaf669. Online ahead of print. ABSTRACT BACKGROUND: Women with HIV (WWH) experience early onset menopause and symptoms may …

Paediatrics

Attempts at quality assurance for pediatric emergency point-of-care ultrasound: A single-center descriptive study

Pediatr Int. 2025 Jan-Dec;67(1):e70285. doi: 10.1111/ped.70285. ABSTRACT OBJECTIVES: Point-of-care ultrasound (POCUS) requires technical expertise, making quality assurance (QA) a major challenge. We evaluated POCUS utilization …

Paediatrics

Azilsartan as an antihypertensive treatment in Japanese children under 6 years old: A phase 3 open-label long-term study

Pediatr Int. 2025 Jan-Dec;67(1):e70284. doi: 10.1111/ped.70284. ABSTRACT BACKGROUND: Pediatric hypertension presents unique challenges in its management and treatment. A previous study demonstrated the safety and …

Paediatrics

Thoracic Skeletal Muscle and Exercise Capacity in Adults With Congenital Heart Disease: A Cross-Sectional Imaging Analysis

J Cachexia Sarcopenia Muscle. 2025 Dec;16(6):e70157. doi: 10.1002/jcsm.70157. ABSTRACT BACKGROUND: The growing population of adults with congenital heart disease (ACHD) faces lifelong morbidities despite advancements …

Paediatrics

Complex Fetal Anomalies: Kluth Type Xc2 Variant Tracheoesophageal Fistula, Srikanth Group III Bronchopulmonary Foregut Malformation, Mirror-Image Dextrocardia with L-Looped Ventricles, Anomalous Coronary Origin from the Pulmonary Artery, and Cardiac-Type Total Anomalous Pulmonary Venous Connection

Pediatr Dev Pathol. 2025 Dec 8:10935266251395235. doi: 10.1177/10935266251395235. Online ahead of print. ABSTRACT We report a fetus at 20 + 5 weeks’ gestation with an …