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Predictive score using umbilical vein leucine-rich α-2 glycoprotein as a useful biomarker for diagnosing histological chorioamnionitis in preterm infants

J Obstet Gynaecol Res. 2025 Jun;51(6):e16344. doi: 10.1111/jog.16344. ABSTRACT AIM: We investigated the value of leucine-rich α-2 glycoprotein (LRG) in cord blood for diagnosing histological …

Analyzing the global burden of 11 subtypes of congenital birth defects: trends, sociodemographic correlates, and outcomes from 1990 to 2021

Ann Med. 2025 Dec;57(1):2519686. doi: 10.1080/07853890.2025.2519686. Epub 2025 Jun 17. ABSTRACT BACKGROUND: Congenital birth defects (CBDs) significantly affect child mortality and disability worldwide, yet regional …

Adjuvant conditioning shapes the adaptive immune response promoting immunotolerance via NLRP3/interleukin-1

iScience. 2025 May 13;28(6):112653. doi: 10.1016/j.isci.2025.112653. eCollection 2025 Jun 20. ABSTRACT Although adjuvants typically enhance immune responses, we show that repeated alum administration-termed adjuvant conditioning …