<span class="vcard">John Joseph</span>
John Joseph

Roflumilast, a phosphodiesterase-4 (PDE4) inhibitor, induces respiratory frequency plasticity that is resistant to inflammation in neonatal rat in vitro preparations

Respir Physiol Neurobiol. 2025 Apr 12:104435. doi: 10.1016/j.resp.2025.104435. Online ahead of print. ABSTRACT Premature and newborn infants often have prolonged apneas and are susceptible to …

Systematic identification of disease-causing promoter and untranslated region variants in 8040 undiagnosed individuals with rare disease

Genome Med. 2025 Apr 14;17(1):40. doi: 10.1186/s13073-025-01464-2. ABSTRACT BACKGROUND: Both promoters and untranslated regions (UTRs) have critical regulatory roles, yet variants in these regions are …

KF1601, a dual inhibitor of BCR::ABL1 and FLT3, overcomes drug resistance in FLT3+ blast phase chronic myeloid leukemia

Mol Cancer. 2025 Apr 14;24(1):114. doi: 10.1186/s12943-025-02292-z. ABSTRACT Blast phase chronic myeloid leukemia (BP-CML) poses significant clinical challenges due to its drug resistance, resulting from …

Clinical effectiveness of drop-in mental health services in paediatric healthcare settings: a non-randomised multi-site study for children, young people and their families

BMC Health Serv Res. 2025 Apr 14;25(1):546. doi: 10.1186/s12913-025-12681-1. ABSTRACT BACKGROUND: Despite the high prevalence of mental health disorders in children and young people with …