<span class="vcard">John Joseph</span>
John Joseph

Esculin induces endoplasmic reticulum stress and drives apoptosis and ferroptosis in colorectal cancer via PERK regulating eIF2α/CHOP and Nrf2/HO-1 cascades

J Ethnopharmacol. 2024 Mar 30:118139. doi: 10.1016/j.jep.2024.118139. Online ahead of print. ABSTRACT ETHNOPHARMACOLOGICAL RELEVANCE: Cortex fraxini (also known as Qinpi), the bark of Fraxinus rhynchophylla …

Clinical prediction models in children that use repeated measurements with time-varying covariates: a scoping review

Acad Pediatr. 2024 Mar 30:S1876-2859(24)00115-3. doi: 10.1016/j.acap.2024.03.016. Online ahead of print. ABSTRACT BACKGROUND: Emerging evidence suggests that clinical prediction models that use repeated (time-varying) measurements …

The CNS microenvironment promotes leukemia cell survival by disrupting tumor suppression and cell cycle regulation in pediatric T-cell acute lymphoblastic leukemia

Exp Cell Res. 2024 Mar 30:114015. doi: 10.1016/j.yexcr.2024.114015. Online ahead of print. ABSTRACT A major obstacle in improving survival in pediatric T-cell acute lymphoblastic leukemia …

Predictors of tumour dynamics over a 6-week course of concurrent chemoradiotherapy for glioblastoma and the impact on survival

Int J Radiat Oncol Biol Phys. 2024 Mar 30:S0360-3016(24)00453-X. doi: 10.1016/j.ijrobp.2024.03.036. Online ahead of print. ABSTRACT PURPOSE: We present the final analyses of tumour dynamics …

Molecular Mechanisms of Medicinal Plant Securinega Suffruticosa-derived Compound Securinine against Spinal Muscular Atrophy based on Network Pharmacology and Experimental Verification

Curr Pharm Des. 2024 Mar 28. doi: 10.2174/0113816128288504240321041408. Online ahead of print. ABSTRACT BACKGROUND: Spinal Muscular Atrophy (SMA) is a severe motor neuronal disorder with …