<span class="vcard">John Joseph</span>
John Joseph

Hypermethylation of lysosomal-associated genes LAMP1 and LAMP2 compromises lysosome function in patients with acute lymphoblastic leukemia

Immunol Res. 2025 Nov 19;73(1):167. doi: 10.1007/s12026-025-09712-8. ABSTRACT DNA methylation plays a pivotal role in the pathogenesis of Acute Lymphocytic Leukemia (ALL), a hematological malignancy …

In vitro study of high-power Er: YAG laser parameters for the management of dentin hypersensitivity in hypomineralized permanent teeth

Lasers Med Sci. 2025 Nov 19;40(1):488. doi: 10.1007/s10103-025-04718-y. ABSTRACT Dentin hypersensitivity (DH) is characterized by intense, short-lasting pain, triggered by dentin exposure to different stimuli. …

Blood and tissue correlates of steroid non-response in checkpoint inhibition-induced immune-related adverse events

Commun Med (Lond). 2025 Nov 18;5(1):472. doi: 10.1038/s43856-025-01164-3. ABSTRACT BACKGROUND: High-dose steroids constitute the cornerstone of first-line treatment for immune-related adverse events (irAEs) associated with …

Incidental cranial suture closure in pediatric patients: a rigorous evaluation of suture closure timing in the era of high-resolution CT

Childs Nerv Syst. 2025 Nov 19;41(1):362. doi: 10.1007/s00381-025-07009-7. ABSTRACT PURPOSE: Classical teaching suggests that major cranial sutures normally close during the third decade of life. …

Double-Blind Randomized Placebo-Controlled Trial of a Lactobacillus Probiotic Blend in Chronic Obstructive Pulmonary Disease

Pulm Ther. 2025 Nov 18. doi: 10.1007/s41030-025-00333-y. Online ahead of print. ABSTRACT INTRODUCTION: Gut microbiota modulate systemic anti-inflammatory and immune responses in the lungs, suggesting …

Acceptability, Relevance, and Short-Term Outcomes of the STAC-T Bullying Bystander App: Feasibility Quantitative Study

JMIR Form Res. 2025 Nov 18;9:e76830. doi: 10.2196/76830. ABSTRACT BACKGROUND: Bullying is a significant public health issue, with approximately 25% of middle school students reporting …