<span class="vcard">John Joseph</span>
John Joseph

Siltuximab monotherapy improves progression free survival compared to rituximab-based therapies in patients with idiopathic multicentric Castleman disease; indirect comparison of studies using single-arm metanalysis method and the generalized linear mixed model

Ann Hematol. 2025 Dec 5. doi: 10.1007/s00277-025-06560-2. Online ahead of print. ABSTRACT Siltuximab is the only approved treatment for idiopathic multicentric Castleman Disease but in …

The triglyceride glucose index as a biomarker for different glucose disorders in overweight and obese children and adolescents

Eur J Pediatr. 2025 Dec 5;184(12):820. doi: 10.1007/s00431-025-06632-5. ABSTRACT The triglyceride/glucose index (TyG index), a formula derived from fasting triglyceride (TG) and glucose levels, has …

Techniques for improvement of success rate in ultrasound-guided radial artery catheterization: a narrative review

J Anesth Analg Crit Care. 2025 Dec 4;5(1):89. doi: 10.1186/s44158-025-00289-0. ABSTRACT Ultrasound-guidance increases success rate and reduces complications compared to traditional palpation for radial artery …

Newborns with ARDS originating from sepsis of extrapulmonary origin exhibit worse prognoses: findings from a multicenter study in China

Eur J Pediatr. 2025 Dec 4;184(12):819. doi: 10.1007/s00431-025-06584-w. ABSTRACT Research on the infection-related etiologies of neonatal acute respiratory distress syndrome (NARDS) remains limited. This study …

The clinical and cost effectiveness of a conservative treatment pathway compared to appendicectomy in children with uncomplicated acute appendicitis: study protocol for a randomised controlled multi-centre open-label parallel-group non-inferiority trial (CONTRACT 2 trial) in the United Kingdom (UK)

Trials. 2025 Dec 4. doi: 10.1186/s13063-025-09282-y. Online ahead of print. ABSTRACT BACKGROUND: Currently, the most frequently used treatment for acute appendicitis in children in the …

A de Novo 2q23.1-2q23.3 duplication in a neonate with anemia, thrombocytopenia, and hypospadias: clinical and genomic characterization

Mol Cytogenet. 2025 Dec 4. doi: 10.1186/s13039-025-00741-4. Online ahead of print. ABSTRACT BACKGROUND: Copy number variations (CNVs) of uncertain significance (VUS) are increasingly identified through …

Overview of pediatric and adult lysosomal acid lipase deficiency: expert recommendations from a Gulf cooperation council working group

Orphanet J Rare Dis. 2025 Dec 5. doi: 10.1186/s13023-025-04158-5. Online ahead of print. ABSTRACT BACKGROUND: Lysosomal acid lipase deficiency (LAL-D) is an autosomal recessive ultrarare …