Front Pediatr. 2025 Jan 29;12:1488731. doi: 10.3389/fped.2024.1488731. eCollection 2024.
ABSTRACT
BACKGROUND: Neonatal hyperbilirubinemia frequently leads to severe neurological damage. Although cranial ultrasound (CUS) is crucial for assessing neonatal brain injury, the association between red blood cell distribution width-coefficient of variation (RDW-CV), a marker of red blood cell size variability, and cranial ultrasound abnormalities (CUAs) remains unclear.
OBJECTIVE: The primary aim of this study was to explore the impact of RDW-CV on CUAs in neonatal hyperbilirubinemia and to elucidate the potential clinical implications of this relationship.
METHODS: This retrospective cross-sectional study included 503 cases of neonatal hyperbilirubinemia at gestational age ≥35 weeks with available RDW-CV and CUS screening data at Nanjing Lishui People’s Hospital. Multivariate logistic regression analysis and smooth curve fitting were used to estimate the association between RDW-CV and the risk of CUAs in neonatal hyperbilirubinemia.
RESULTS: This study found that the overall prevalence of CUAs in ultrasound images was 26.0%. Multivariate logistic regression analysis adjusted for risk factors revealed that a one-percent increase in RDW-CV increased the risk of CUAs by 23.0%. After conducting a sensitivity analysis of the three RDW-CV quantiles, the findings remained robust and consistent.
CONCLUSIONS: The study concluded that a higher RDW-CV was associated with a proportional increase in the risk of CUAs. These results demonstrate the importance of RDW-CV in neonatal hyperbilirubinemia. Clinicians should consider this association when managing patients with high RDW-CV.
PMID:39944130 | PMC:PMC11814458 | DOI:10.3389/fped.2024.1488731
