J Med Virol. 2025 Nov;97(11):e70689. doi: 10.1002/jmv.70689.
ABSTRACT
Cytomegalovirus (CMV) is a leading cause of congenital infections, with glycoproteins B (gB), H (gH), and O (gO) critical for viral pathogenesis. However, the role of these glycoprotein variabilities in determining the outcomes of CMV infection remains controversial. Here, we investigated clinical characteristics, CMV glycoprotein genotypes (gB, gH, and gO), and mannose-binding lectin 2 (MBL2) genetic variants in 108 CMV-infected newborns in Shanghai. Results showed dominance of gB1 (57.7%), gH1 (61%), gO1 (30.5%), and HYPA haplotype (34.8%), with a novel gB3-gH1 co-expression pattern identified for the first time. The results demonstrated that gH2 was associated with purpura/petechiae, the gH1-gO1 combination was associated with low virulence and asymptomatic infection, and low MBL expression was correlated with severe retinopathy. Additionally, our data showed that the gB3-gH1 combination was associated with hearing loss in CMV-infected neonates. These findings indicate that gB, gH, gO, and MBL2 polymorphisms correlate with outcomes of CMV infection in infants.
PMID:41200871 | DOI:10.1002/jmv.70689
