Clin Ter. 2025 May_Jun;176(3):358-362. doi: 10.7417/CT.2025.5234.
ABSTRACT
OBJECTIVE: The purpose of this study is to determine whether or not ampicillin, following a standard prophylactic dose against group B streptococcal infection, reaches concentrations above the minimum inhibitory concentrations (MIC) in maternal plasma and umbilical cord blood (UCB).
PATIENTS AND METHODS: From January 2024 to December 2024, this prospective study was conducted at Al-Azhar and Helwan University Hospitals and included 200 newborns whose moms had received intrapartum ampicillin. There were 200 maternal plasma samples and 200 UCB samples available for examination (between 5 and 75 minutes postpartum).
RESULTS: As fast as five minutes after ampicillin infusion, the mean ampicillin concentrations found in maternal and umbilical cord sera all surpassed the lowest bactericidal values documented for group B streptococci (0.25 to 2.0 micrograms/ml).
CONCLUSION: Neonatal quantities of ampicillin over the MIC of GBS are the result of intrapartum dosing.
PMID:40525369 | DOI:10.7417/CT.2025.5234
