Pediatr Res. 2025 Nov 19. doi: 10.1038/s41390-025-04622-9. Online ahead of print.
ABSTRACT
Childhood-onset Takayasu arteritis (cTAK) is not a uniform disease but exhibits distinct age-specific clinical and vascular phenotypes across developmental stages, from infants to adolescents. These differences necessitate age-tailored diagnostic approaches and therapeutic strategies to improve outcomes and reduce treatment-related morbidity. The concept of “developmental vasculopathy” links vascular involvement patterns to maturational changes in the arterial wall, addressing critical diagnostic challenges in differentiating incomplete Kawasaki disease from cTAK. The progression toward age-stratified management patterns heralds a new era of personalized medicine in cTAK, with precision diagnostics and tailored interventions to improve outcomes for this serious childhood disease.
PMID:41261162 | DOI:10.1038/s41390-025-04622-9
