J Pediatr Health Care. 2025 Mar 7:S0891-5245(25)00057-4. doi: 10.1016/j.pedhc.2025.02.003. Online ahead of print.
ABSTRACT
INTRODUCTION: This study examined lung function trajectory (FEV1 % predicted) in children with asthma and explored the influence of sex and asthma control on these trajectories.
METHODS: A retrospective cohort study used a latent growth curve model (LGCM) to analyze the FEV1 trajectory in children with asthma.
RESULTS: FEV1 followed a quadratic trajectory with significant individual variability. Males exhibited a significantly slower rate of FEV1 change compared to females (estimate = -1.029, p < .001) but a higher acceleration rate (estimate = 0.269, p < .001). Improved asthma control was associated with a significant enhancement in FEV1 over time (p < .01).
DISCUSSION: FEV1 growth followed a curvilinear trajectory, marked by gradual deceleration. Males had slower initial growth but greater acceleration. Asthma control significantly influenced lung function improvement.
PMID:40057852 | DOI:10.1016/j.pedhc.2025.02.003
