Front Endocrinol (Lausanne). 2024 Mar 19;15:1184966. doi: 10.3389/fendo.2024.1184966. eCollection 2024.
ABSTRACT
AIM: To evaluate the effect of an extended culture period on birth weight among singletons born after vitrified-warmed embryo transfer.
METHODS: A retrospective cohort study was performed among 12400 women who gave birth to 1015, 1027, 687, and 9671 singletons after single blastocyst transfer, single cleavage-stage embryo transfer, double blastocyst transfer, and double cleavage-stage embryo transfer, respectively.
RESULTS: The unadjusted birth weight of singletons born after vitrified blastocyst transfer were heavier than those born after cleavage-stage transfer (β=30.28, SE=13.17, P=0.022), as were the adjusted birth weights (β=0.09, SE=0.03, P=0.007). In addition, there was a 37% increased odd of having an infant with high birth weight after vitrified blastocyst transfer compared with vitrified cleavage stage transfer (OR=1.37, 95% CI:1.07-1.77).
CONCLUSION: The unadjusted and adjusted birth weight and odds of having an infant with high birth weight significantly increased after blastocyst transfer compared with cleavage-stage embryo transfer in vitrified-warmed cycles.
PMID:38567304 | PMC:PMC10985195 | DOI:10.3389/fendo.2024.1184966
