Vaccine. 2025 Dec 25;73:128144. doi: 10.1016/j.vaccine.2025.128144. Online ahead of print.
ABSTRACT
INTRODUCTION: We aimed to evaluate immunological memory after three different single-dose hepatitis A vaccination schedules.
METHODS: Children were vaccinated using one of three schedules: 1) Twinrix®Junior at 12 months (Twinrix12); 2) Vaqta®pediatric at 13 months (Vaqta13); or 3) Vaqta®pediatric at 19 months of age (Vaqta19), followed by a challenge dose with Twinrix®Junior three years later. Blood samples were collected before and one month post-challenge dose.
RESULTS: A total of 320 children were included in this analysis. Seropositivity (≥20 mIU/mL) three years post-primary vaccination was lower for the Twinrix12 schedule (40.2 %) compared to the Vaqta13 (65.6 %) or Vaqta19 schedules (77.6 %). One month post-challenge dose, the proportion of participants with an anamnestic response was high and similar across the three schedules (Twinrix12: 97.5 %; Vaqta13: 98.4 %; Vaqta19: 96.1 %).
CONCLUSION: Single-dose hepatitis A vaccination induced a strong immune response across the three schedules. However, further studies are needed to confirm long-term durability and population impact.
PMID:41453243 | DOI:10.1016/j.vaccine.2025.128144
