J Perinatol. 2025 Nov 27. doi: 10.1038/s41372-025-02481-0. Online ahead of print.
ABSTRACT
OBJECTIVE: To quantify inter-center variation (ICV) in length of stay (LOS) among surviving infants with jejunal (JA) or ileal atresia (IA).
STUDY DESIGN: Children’s Hospitals Neonatal Consortium’s database was used to identify infants with JA or IA. After excluding infants with abdominal wall defects, survivors’ hospital LOS was modeled as a function of center using generalized linear models with log link for gamma distribution.
RESULTS: There were 1134 and 808 infants with JA and IA, respectively. LOS had significant ICV in unadjusted (JA: 5.4 [IQR 3.7,9.9] weeks; IA: 4.3 [IQR 2.4,11.4] weeks) and multivariable analyses (JA: 4+ fold difference (6.5-31.5 week); p < 0.001 IA: 8+ fold difference (1.7-14.6 weeks); p < 0.001) with modifiable risk factors including cholestasis, ostomy creation, blood stream infection, and residual bowel length <55 cm.
CONCLUSION: Risk-adjusted ICV in LOS was observed in infants with JA and IA, which exposes opportunities for improvements in outcomes for infants with intestinal atresia.
PMID:41310308 | DOI:10.1038/s41372-025-02481-0
