Nervenarzt. 2025 Nov 27. doi: 10.1007/s00115-025-01929-0. Online ahead of print.
ABSTRACT
BACKGROUND: Affective disorders are associated with an enormous disease burden, necessitating research on the mechanisms of effective treatments.
OBJECTIVES: This article introduces the intervention projects of the transregional Collaborative Research Center 393 (CRC/TRR 393). By employing targeted interventions, we aim to induce modifiability in the key mechanisms underlying the trajectories of affective disorders studied in CRC/TRR 393: emotion regulation, expectation, social cognition, and (circadian) cognitive-behavioral rhythms.
MATERIALS AND METHODS: The longitudinal design of the CRC/TRR 393 study will examine four interventions targeting specific mechanisms in subgroups of the German Mental Health Cohort (GEMCO). GEMCO includes patients with a current or lifetime diagnosis of major depressive disorder (MDD), bipolar disorder (BD), and healthy control (HC) participants. Multilevel measurements of these targeted mechanisms will allow us to investigate their fine-grained modifiability and their effects on disease trajectories.
RESULTS: The results will provide insights into how these mechanisms can be modified. Together with the CRC/TRR 393 mechanisms projects, we will examine the effects of key cognitive-emotional mechanisms on disease trajectories.
CONCLUSION: For the first time, the modifiability of four key mechanisms underlying the trajectories of affective disorders will be investigated both cross-sectionally and longitudinally.
PMID:41307581 | DOI:10.1007/s00115-025-01929-0
