Pediatr Neonatol. 2025 Nov 13:S1875-9572(25)00201-3. doi: 10.1016/j.pedneo.2025.06.010. Online ahead of print.
ABSTRACT
BACKGROUND: Bronchopulmonary dysplasia (BPD) significantly impacts neonatal care. Early risk identification is vital for clinical decisions. Jensen’s updated BPD definition aims to predict health problems in young children, but the relationship between cumulative oxygen fractions (FiO2), mean airway pressure (MAP), and BPD severity is unclear.
METHODS: This single-center, retrospective cohort study analyzed newborns with a birth weight under 1500 g. We calculated cumulative areas under the curve for hourly FiO2, MAP, and respiratory severity score (RSS) within 14 days post-birth. Logistic regression identified postnatal factors linked to outcomes: death after 14 days, BPD diagnosis, and severity. A multinomial model assessed the relationship between cumulative hourly FiO2, MAP, and RSS across different postnatal periods and BPD severity.
RESULTS: Among 250 infants, 2.4 %, 44 %, and 4 % had grade I, II, and III BPD, respectively, with an overall mortality rate of 4.5 %. Cumulative MAP in the first week, second week, and all 14 days was associated with mortality. Cumulative RSS during these periods was significantly related to BPD development. Additionally, cumulative FiO2 and RSS during these times effectively differentiated BPD severity.
CONCLUSION: The ventilatory support and FiO2 within 14 days after birth were associated with mortality and Jensen’s definition of BPD.
PMID:41271516 | DOI:10.1016/j.pedneo.2025.06.010
