Am J Infect Control. 2025 Nov 14:S0196-6553(25)00715-1. doi: 10.1016/j.ajic.2025.11.011. Online ahead of print.
ABSTRACT
BACKGROUND: This study documents an outbreak of HAdV keratoconjunctivitis originating in the ophthalmology department of a tertiary hospital and spreading to neonatal intensive care unit (NICU).
METHODS: Following ORION guidelines, Hospital Infection Control Committee (ICC) launched an investigation after clusters of keratoconjunctivitis in healthcare workers (HCWs) reported over four-weeks. Patient records were reviewed, environmental and patient samples collected, and PCR analyses performed. Infection control measures (ICMs) were implemented, and their effectiveness assessed through follow-up testing. The institutional burden of the outbreak was analyzed.
RESULTS: Twelve HCWs were affected (eight ophthalmology, four NICU). PCR confirmed HAdV in conjunctival swabs from 11 tested individuals, including cases infected more than three weeks earlier. Viral contamination was detected on 10/16 environmental surfaces in the ophthalmology clinic. Genotyping identified HAdV type-8. The outbreak imposed major operational burdens, especially workforce loss. Chlorine solution achieved rapid surface disinfection, while 0.36% hydrogen peroxide required repeated applications for chlorine-sensitive devices. Following enhanced disinfection protocols and temporary clinic closure during a holiday, no new cases occurred.
DISCUSSION: This outbreak, which continued until the ICC intervened, underlines the high environmental contamination of HAdV and the critical importance of a swift, evidence-based and multidisciplinary response.
CONCLUSION: This study demonstrates that targeted disinfection and strict ICMs are essential for containing such outbreaks and mitigating their significant operational and financial impact on healthcare institutions.
PMID:41242359 | DOI:10.1016/j.ajic.2025.11.011
