Saudi Dent J. 2025 Nov 1;37(10-12):73. doi: 10.1007/s44445-025-00079-y.
ABSTRACT
Desensitizing toothpastes are considered an effective treatment option for managing dentin hypersensitivity (DH). This review evaluated existing systematic reviews and meta-analyses to determine the effectiveness of toothpastes containing calcium sodium phosphosilicate (CSPS) in managing DH. A comprehensive search was conducted in PubMed, Embase, Scopus, Cochrane, and Web of Science databases. Two reviewers performed study selection, data extraction, methodological quality assessment (using the AMSTAR 2 tool) and risk of bias (RoB; using the ROBIS tool) evaluation. The primary randomized clinical trials overlap was assessed using a citation matrix and calculating the overlap percentage, covered area (CA), and corrected covered area (CCA). A total of 5681 studies were identified and the full text of 85 studies were assessed. Finally, nine reviews were included in the umbrella review. A very high overlap was observed across primary studies. Eight studies had a low or critically low quality. Two reviews demonstrated a low RoB across all domains. CSPS-containing toothpastes were found to be more effective in relieving DH than placebo and negative controls. CSPS-containing toothpastes may be effective in relieving the pain associated with DH. However, the considerable heterogeneity and generally low methodological quality of the available evidence warrant cautious interpretation.
PMID:41175303 | DOI:10.1007/s44445-025-00079-y
