Cureus. 2025 Sep 19;17(9):e92692. doi: 10.7759/cureus.92692. eCollection 2025 Sep.
ABSTRACT
In children, the lupus anticoagulant (LA) is transiently produced after infection and rarely causes bleeding tendency, known as LA-hypoprothrombinemia syndrome (LAHPS). In this case report, we describe a child presenting with difficulty standing and walking after enterocolitis and complicated false coagulation abnormalities. Prolonged prothrombin time and activated partial thromboplastin time (APTT); decreased factors II, VIII, IX, XI, and XII; and inhibitors for factors VIII and IX were detected. On the basis of such findings as inhibitor pattern in the APTT cross-mixing test and positivity for serum LA, LAHPS was diagnosed. Physicians should be aware of the interference by LA with phospholipid-based coagulation tests, leading to the misinterpretation of the unusual coagulation abnormalities in LAHPS.
PMID:41116939 | PMC:PMC12535680 | DOI:10.7759/cureus.92692
