Fetal Pediatr Pathol. 2025 Sep 27:1-6. doi: 10.1080/15513815.2025.2565690. Online ahead of print.
ABSTRACT
Hyperbilirubinemia is a common problem during the neonatal period, which can lead to high morbidity and mortality if it is not treated properly. The most common first-line treatment used for hyperbilirubinemia is phototherapy. Glucose-6-phosphate dehydrogenase deficiency (G6PD) can cause indirect hyperbilirubinemia not only with hemolysis but also by affecting bilirubin metabolism in the liver during the neonatal period. In here, we report a three-day-old newborn with severe hyperbilirubinemia who underwent exchange transfusion with a diagnosis of G6PD deficiency to emphasize the importance of keeping in mind erythtocyte enzyme defects in the differential diagnosis of severe indirect hyperbilirubinemia.
PMID:41014011 | DOI:10.1080/15513815.2025.2565690
