J Clin Transl Sci. 2025 Aug 27;9(1):e202. doi: 10.1017/cts.2025.10122. eCollection 2025.
ABSTRACT
Prospective consent in neonatal research poses significant challenges, particularly during urgent, time-sensitive clinical windows of study enrollment. This is especially true at referral centers for large geographic regions. A partial waiver of consent offers a potential translational science approach to enhance access to research participation in critically ill neonates. We compared enrollment rates in a study evaluating pulse oximetry accuracy across neonates with varying skin pigmentation before and after implementing a partial waiver of consent. Overall enrollment increased significantly without creating a racial disparity in enrollment, thereby improving generalizability and efficiency in neonatal clinical research.
PMID:40994669 | PMC:PMC12454670 | DOI:10.1017/cts.2025.10122
