J Matern Fetal Neonatal Med. 2025 Dec;38(1):2548987. doi: 10.1080/14767058.2025.2548987. Epub 2025 Sep 22.
ABSTRACT
INTRODUCTION: This study evaluated the effect of preterm premature rupture of membranes (PPROM) on neonatal outcomes in low-birth-weight infants.
METHODS: We included premature infants born in our hospital and divided them into PPROM group and non-PPROM group. Maternal and neonatal data were collected, and follow-up assessments were performed at 3, 6, and 9 months of corrected age.
RESULTS: The PPROM group had significantly lower birth weights, gestational ages, higher maternal infection rates, longer hospital stays, and higher complication rate (p < 0.001). PPROM, 5-minute Apgar score <7, and birth weight <1500 g was significant risk factors for complications (p < 0.001). Birth weight <1500 g, sepsis, premature encephalopathy, asphyxia and necrotizing enterocolitis (p < 0.01) were significant predictors of death. Infants with PPROM duration >7 days had the highest mortality rate and lower mental development index scores at 3 months (p < 0.05).
CONCLUSION: PPROM significantly impacts neonatal outcomes in low-birth-weight infants, leading to higher complication rates and longer hospital stays, which is associated with high risk of neonatal complication.
PMID:40983506 | DOI:10.1080/14767058.2025.2548987
