Endocrinol Diabetes Nutr (Engl Ed). 2025 Sep 12:501593. doi: 10.1016/j.endien.2025.501593. Online ahead of print.
ABSTRACT
INTRODUCTION: Recent studies suggest a higher prevalence of attention-deficit hyperactivity disorder (ADHD) in transgender individuals compared to the general population. However, no studies have been conducted in the Spanish population, and most focus on individuals with a prior ADHD diagnosis rather than screening for the disorder.
MATERIALS AND METHODS: This is a single-center, cross-sectional observational study assessing the risk of ADHD in transgender adolescents and young adults compared to cisgender individuals using the World Health Organization’s (WHO) Adult ADHD Self-Report Scale (ASRS-V1.1). Additionally, previous mental health diagnoses and experiences of discrimination are analyzed in both groups.
RESULTS: Transgender youth scored higher on the short-form scale, indicating a greater risk of ADHD, as well as on the hyperactivity/impulsivity subscale. A significant association was also found between experiences of discrimination and a prior diagnosis of depression.
CONCLUSIONS: The ASRS-V1.1 scale may be useful for ADHD screening in transgender individuals; however, further studies are needed to confirm these findings. Risk factors for neurodevelopmental and anxiety-depressive disorders may differ in the transgender population.
PMID:40946028 | DOI:10.1016/j.endien.2025.501593
