J Obstet Gynaecol Res. 2025 Sep;51(9):e70020. doi: 10.1111/jog.70020.
ABSTRACT
PURPOSE: Preterm premature rupture of membranes (PPROM) is a major contributor to preterm birth and is associated with increased risks of maternal and neonatal complications. The aim of this review is to summarize current antibiotic strategies and explore emerging adjunctive therapies, including probiotics, amnioinfusion, and fetal membrane repair, to improve the management of PPROM.
METHODS: Relevant literature on antibiotic therapy for PPROM and emerging treatment strategies was systematically retrieved from PubMed. The data were analyzed to compare standard antibiotic protocols with personalized and combination regimens.
RESULTS: Evidence indicates that adjusting antibiotic duration and adopting precision-based regimens may improve clinical efficacy while minimizing adverse effects. Moreover, probiotics, amnioinfusion, and fetal membrane repair hold promise in alleviating infection-related inflammation and improving pregnancy outcomes.
CONCLUSIONS: Optimizing antibiotic therapy via individualized approaches and incorporating adjunctive treatments could enhance the management of PPROM. Future research ought to concentrate on pinpointing biomarkers for personalized antibiotic selection, evaluating combination therapies, and assessing long-term maternal-fetal outcomes.
PMID:40930504 | DOI:10.1111/jog.70020
