Pediatr Blood Cancer. 2025 Aug 13:e31989. doi: 10.1002/pbc.31989. Online ahead of print.
ABSTRACT
Medulloblastoma, the most prevalent malignant brain tumor in children, typically requires a multimodal treatment approach including surgery, chemotherapy, and craniospinal radiation. Chemotherapy is particularly crucial in controlling tumor growth in young children (<3-5 years old), where craniospinal radiation is often avoided due to its detrimental neurocognitive side effects. This report highlights two remarkable young children with metastatic SHH-medulloblastoma who presented with severe and life-threatening neurological symptoms. Following emergency administration of intensive chemotherapy, both patients demonstrated rapid and significant clinical and radiological response, underscoring the potential use of chemotherapy as a salvage therapy in such critical situations.
PMID:40880101 | DOI:10.1002/pbc.31989
