J Perinatol. 2025 Jul 28. doi: 10.1038/s41372-025-02345-7. Online ahead of print.
ABSTRACT
OBJECTIVE: To perform three studies needed to design the “U-BET” trial (Umbilical cord Blood for Extremely-low-gestational-age Transfusions).
STUDY DESIGN: (1) Survey-based self-assessment of Intermountain Health obstetricians regarding drawing umbilical cord blood. (2) Determine the percentage of the potentially donating neonates who have type O blood (to be utilized in U-BET). (3) Quantify cord blood drawn using American Red Cross collection kits.
RESULTS: (1) 72% of respondents declared experience drawing cord blood; 62% with the placenta in utero. (2) Of the past 100,000 women delivering, 48% were type O, and 66% of neonates born to them were type O. (3) The volume of cord blood obtained at 10 births ranged from 20 to 86 mL after the placenta was delivered vs. 14 to157 mL when in utero.
CONCLUSION: The U-BET trial will consent type O women and use Red Cross kits to draw term umbilical cord blood while the placenta is still in utero.
PMID:40721652 | DOI:10.1038/s41372-025-02345-7
