Rheumatology (Oxford). 2025 Jul 17:keaf393. doi: 10.1093/rheumatology/keaf393. Online ahead of print.
ABSTRACT
OBJECTIVE: Axial spondyloarthritis (axSpA) is a chronic inflammatory disease predominantly affecting the spine and sacroiliac joints. Nonsteroidal anti-inflammatory drugs (NSAIDs) are first-line therapy, but individual responses vary widely. We evaluated the efficacy and patient preference of three NSAIDs (celecoxib, meloxicam, and naproxen) through Bayesian N-of-1 clinical trials to optimize axSpA management.
METHODS: We conducted N-of-1 trials with 42 patients meeting ASAS criteria for axSpA. Each patient was asked to complete two cycles of randomized double-blind crossover comparisons of the three NSAIDs, each for 4 weeks. The primary endpoint was the change in the Ankylosing Spondylitis Disease Activity Score (ASDAS). Bayesian analysis assessed the average treatment effect of each NSAID based on individual patient responses.
RESULTS: Thirty patients completed the trial series. All three NSAIDs resulted in reductions in ASDAS overall across all individuals (posterior probability of benefit [PPB] >0.99 of > 0 reduction). No single NSAID demonstrated superiority across all patients. Patient preferences varied, with individualized responses to NSAID therapy identified through Bayesian analysis. The preferred NSAID for each patient showed a larger reduction in ASDAS compared to the least effective NSAID (0.88 vs. 0.12, PPB >0.99), with potential clinically important improvement (PPB [0.6]=0.96).
CONCLUSIONS: Applying N-of-1 trials and Bayesian analysis effectively optimized NSAID therapy for axSpA in terms of efficacy and accounting for side effect profile. This approach raises the possibility of more efficient systemic individualization than usual care.
PMID:40676732 | DOI:10.1093/rheumatology/keaf393
