Zhonghua Yu Fang Yi Xue Za Zhi. 2025 Jul 6;59(7):1118-1124. doi: 10.3760/cma.j.cn112150-20241101-00869.
ABSTRACT
The prevalence of cardiovascular diseases among children and adolescents continues to escalate, with cardiometabolic risk factors emerging as primary contributors to this concerning trend. Key contributing factors encompass obesity, diabetes mellitus, and hypertension. This developmental phase represents a crucial window for both physical maturation and psychological growth. Previous studies have demonstrated significant associations between cardiovascular pathologies and mental health outcomes. Given their immature physiological and psychological regulatory systems, children and adolescents exhibit heightened susceptibility to emotional dysregulation, predominantly manifesting as anxiety disorders and depressive conditions.Current research remains limited in elucidating the complex relationship between cardiometabolic risk profiles and affective disorders within this vulnerable population. Emerging evidence suggests that cardiometabolic disturbances may potentiate the pathogenesis and progression of mood disorders through multifaceted mechanisms including oxidative stress pathways, neuroendocrine system dysregulation, and maladaptive lifestyle patterns. However, substantial gaps persist in our understanding of the precise pathophysiological interactions underlying this association.This comprehensive review systematically examines the interconnection between cardiometabolic risk parameters and emotional disorders in pediatric populations. This article critically evaluate current assessment methodologies, epidemiological patterns, and clinical correlations while proposing mechanistic frameworks that integrate biochemical, neurological, and behavioral pathways. The analysis emphasizes the need for interdisciplinary approaches to address this pressing public health challenge.
PMID:40661023 | DOI:10.3760/cma.j.cn112150-20241101-00869
