BJOG. 2025 Jul 14. doi: 10.1111/1471-0528.18280. Online ahead of print.
ABSTRACT
BACKGROUND: Controversy persists over whether preimplantation genetic testing (PGT) increases adverse maternal and neonatal outcomes.
OBJECTIVES: To quantify the risk of maternal and neonatal outcomes for singleton and multiple pregnancies conceived after PGT versus those conceived after IVF/ICSI.
SEARCH STRATEGY: PubMed, Embase, Web of Science, and Cochrane Central Register of Controlled Trials were searched from January 1990 to May 2025.
SELECTION CRITERIA: Randomised controlled trials (RCTs) and observational studies separately reporting outcomes in singleton and multiple pregnancies.
DATA COLLECTION AND ANALYSIS: Random-effects models were used for calculating relative risks (RRs) or standardised mean differences (SMDs) with 95% confidence intervals (CIs).
MAIN RESULTS: Forty-two studies (43 663 PGT cases and 217 002 IVF/ICSI cases) were included for further analysis. The risks of very low birth weight (VLBW) (RR 0.66; 95% CI 0.58, 0.76), preterm birth (PTB) < 34 weeks (RR 0.79; 95% CI 0.73, 0.86), PTB < 32 weeks (RR 0.68; 95% CI 0.52, 0.89), and PTB < 28 weeks (RR 0.59; 95% CI 0.35, 0.99) in PGT singleton pregnancies were significantly lower than those in IVF/ICSI singleton pregnancies, and the risk of PTB < 32 weeks (RR 0.62; 95% CI 0.45, 0.86) in PGT multiple pregnancies was notably reduced compared to that in IVF/ICSI multiple pregnancies. The two groups showed comparable maternal outcome risks in singleton and multiple pregnancies.
CONCLUSIONS: Nonetheless, no decisive conclusions can be drawn due to the low quality of evidence and challenges of statistical hypothesis testing. Additional high-quality RCTs with larger sample sizes and stringent methodologies are warranted to validate these findings.
PMID:40654038 | DOI:10.1111/1471-0528.18280
