Vaccine. 2025 Jul 12;62:127481. doi: 10.1016/j.vaccine.2025.127481. Online ahead of print.
ABSTRACT
The optimal timing of pertussis vaccination in pregnancy is debated, especially to maximise antibody concentrations in infants born preterm. This study investigated immunoglobulin G (IgG) in preterm infants at 5 and 12 months, whose mothers had received a pertussis-containing vaccine at different gestations or were unvaccinated. Results show that vaccination in the early-mid second trimester may result in increased FHA specific IgG concentrations in preterm infants at 5 and 12 months. The BEAR PAW study used residual serum samples from the BEAR Men B study (Babies born Early Antibody Response to Men B vaccination (NCT03125616)).
PMID:40652683 | DOI:10.1016/j.vaccine.2025.127481
