Biol Psychiatry. 2025 Jul 4:S0006-3223(25)01302-2. doi: 10.1016/j.biopsych.2025.06.028. Online ahead of print.
ABSTRACT
BACKGROUND: Expanding our previous findings that model-based/model-free (MB/MF) control-often conceptualized as goal-directed and habitual behavior-at age 18 is associated with alcohol drinking trajectories over three years, this study investigates whether changes in MB/MF control from ages 18 to 21 i) stem from alcohol exposure and ii) predict drinking patterns up to age 24.
METHODS: We followed a community sample of 124 18-year-old young men for six years. At ages 18 and 21, participants performed a two-step task assessing MB and MF control while undergoing functional magnetic resonance imaging (91 neural datasets). Drinking behavior was assessed using annual interviews complemented by questionnaires every six months. Correlation coefficients assessed the effect of cumulative alcohol exposure from age 18 to 21 on changes in MB/MF parameters. Latent growth curve models evaluated associations between MB/MF changes and drinking trajectories from ages 21 to 24.
RESULTS: Alcohol exposure from ages 18 to 21 showed no significant effect on changes of MB/MF control. An increased MB behavioral score was protective for binge drinking, while an increased MF behavioral score predicted higher binge drinking at age 21, but not its future development. Changes in MF ventral striatum signals were associated with escalated consumption score development from ages 21 to 24, whereas MF ventromedial prefrontal signals exhibited a protective effect.
CONCLUSIONS: Preceding changes in behavioral and neural MB and MF control were linked to future drinking patterns, suggesting that interventions aimed at modulating MB/ MF controls could help mitigate subsequent risky drinking behaviors.
PMID:40618945 | DOI:10.1016/j.biopsych.2025.06.028
