Mol Syndromol. 2025 May;16(3):216-222. doi: 10.1159/000542064. Epub 2024 Nov 29.
ABSTRACT
INTRODUCTION: The incidence of depression in adolescents is increasing and is associated with severe cognitive impairment. This paper aimed to investigate the relationship between polymorphisms in microRNA-146a-5p (miR-146a-5p) and cognitive impairment in adolescent depression patients.
METHODS: Quantitative real-time polymerase chain reaction was used to quantify miR-146a-5p in serum. Detection of miR-146a-5p gene polymorphism was performed by TaqMan SNP Genotyping Assay. Odds ratios and 95% confidence intervals (CIs) were calculated by chi-square test (χ2) and logistic regression analysis.
RESULTS: Genotyping of miR-146a rs2910164 showed that CC (OR = 0.443, 95% CI, 0.264-0.741, p = 0.002) and GC (OR = 0.445, 95% CI, 0.279-0.712, p = 0.001) genotype reduced the risk of cognitive impairment in adolescent depression. The C allele (OR = 0.794, 95% CI, 0.694-0.741, p = 0.001) was a protective factor for cognitive impairment in adolescent depression compared to the rs2910164 G allele. Rs2910164 (OR = 0.425, 95% CI = 0.273-0.662, p = 0.000) showed a negative correlation with adolescents with cognitive impairment in depression by logistic regression analysis. The level of miR-146a-5p was decreased in carriers of the CC and CG genotypes.
CONCLUSION: Rs2910164 C allele carriers have a low risk of cognitive impairment in adolescent depression and could reduce miR-146a-5p level.
PMID:40475169 | PMC:PMC12136548 | DOI:10.1159/000542064
