Diabetes Care. 2025 May 19:dc242891. doi: 10.2337/dc24-2891. Online ahead of print.
ABSTRACT
OBJECTIVE: We tested associations of type 2 diabetes genetic risk score (T2D-GRS) and exposure to maternal hyperglycemia with childhood impaired glucose tolerance (IGT) and T2D and glycemic outcomes in youth from the Hyperglycemia and Adverse Pregnancy Outcome Follow-Up Study.
RESEARCH DESIGN AND METHODS: We calculated T2D-GRS using 1,150 known genetic variants associated with T2D in adults. In utero exposures included gestational diabetes (GDM) and sum-of-glucose z scores during oral glucose tolerance test at ∼28 weeks’ gestation. IGT + T2D and continuous glycemic outcomes were measured when children were 10-14 years old.
RESULTS: In 3,444 children (mean age, 11.4 years), higher maternal sum-of-glucose z scores and child T2D-GRS were both associated with higher glucose levels. In children exposed to GDM and with T2D-GRS >75th percentile, 15.9% had IGT + T2D, compared with 5.6% in nonexposed children.
CONCLUSIONS: High genetic risk for diabetes and in utero exposure to maternal hyperglycemia are additively associated with IGT + T2D and glycemic outcomes in youth.
PMID:40388117 | DOI:10.2337/dc24-2891
