Eur Child Adolesc Psychiatry. 2025 Mar 18. doi: 10.1007/s00787-025-02662-4. Online ahead of print.
ABSTRACT
Folate and vitamin B12 are associated with neurodevelopment and neurotransmitter synthesis and insufficiencies of these nutrients could be linked to psychiatric disorders in children and adolescents. To assess serum levels of folate and B12 in child and adolescent psychiatric inpatients and examine possible links between these levels and different psychiatric disorders. Child and adolescent psychiatric inpatients admitted in a general hospital during a 3-year period were included for analysis. Folate and B12 levels were measured when the subjects were admitted. Psychiatric diagnoses were made following DSM-5 criteria and grouped into categories. Logistic regression analysis was used to study the effects of socio-demographic variables as well as folate and B12 levels, insufficiencies and deficits as possible predictors of outcome (psychiatric diagnostic category). 729 inpatients (60.6% female, mean age: 15.1 ± 2 years) were included. A total of 42.9% presented insufficient folate levels and 19.4% insufficient B12 levels. Insufficient B12 levels were associated with depressive disorders in the multivariate model (OR = 0.82, p = 0.002) as was female sex (OR = 1.65, p = 0.007). Moreover, low vitamin B12 levels were linked to schizophrenia spectrum disorders (SSD, OR = 0.9982, p = 0.024). In contrast, higher folate (OR = 1.15, p < 0.001) and vitamin B12 levels (1.0024, p = 0.002) as well as female sex (OR = 7.86, p < 0.001) were associated with eating disorders. Insufficient or low B12 levels could help predict depressive and SSD respectively in child and adolescent psychiatric inpatients. Further study could help us better understand the impact of this insufficiency during the neurodevelopmental period and the potential benefits of nutritional interventions.
PMID:40100400 | DOI:10.1007/s00787-025-02662-4
