Int J Environ Health Res. 2025 Feb 19:1-13. doi: 10.1080/09603123.2025.2467820. Online ahead of print.
ABSTRACT
BACKGROUND: Household cleaning agents promote hygiene along with causing respiratory effects, especially pediatric asthma. This systematic review quantified the association between exposure to household cleaning agents and pediatric asthma.
METHOD: Five databases were searched. Data were analyzed qualitatively and quantitatively. RevMan 5.4 calculated odds ratios (OR) with 95% confidence intervals (CI), and a funnel plot assessed publication bias. The Mixed Methods Appraisal Tool (MMAT) and GRADE framework assessed methodological quality and certainty respectively.
RESULTS: Sixteen studies met the eligibility criteria. Meta-analysis showed a significant association between the use of household cleaning agents and pediatric asthma (OR 2.90 (95% CI: 2.13-3.95; p < 0.01, I2 = 98%). Exposure stages also showed significant (p < 0.01) association with household cleaning agents (OR 2.92 (95% CI: 2.12-4.03, I2 = 98%). No publication bias or high risk of bias was found.
CONCLUSION: A strong association between exposure to household cleaning agents and an increased risk of pediatric asthma was found. .
PMID:39970329 | DOI:10.1080/09603123.2025.2467820
